Удаляем стандартный dnslookup:
begin routers
    dnslookup:
        driver = dnslookup
        domains = !+local_domains
        transport = remote_smtp
        ignore_target_hosts = 0.0.0.0 : 127.0.0.0/8
        no_more
Добавляем в секцию routers:
begin routers
   example_router:
        driver = manualroute
        domains = !+local_domains
        transport = example_smtp
        route_list = * smtp.example.com
Удаляем стандартный транспорт remote_smtp из секции transports:
begin transports
    remote_smtp:
        driver = smtp
Добавляем новый транспорт в секцию transports:
begin transports
    example_smtp:
        driver = smtp
        hosts = smtp.example.com